After cryptogenic stroke, make prevention the priority

By closing a PFO associated with a cryptogenic stroke with the Amplatzer™ PFO Occluder, you can significantly reduce your patient’s risk of stroke recurrence.
Find out moreBy closing a PFO associated with a cryptogenic stroke with the Amplatzer™ PFO Occluder, you can significantly reduce your patient’s risk of stroke recurrence.
Find out moreAbbott created the PFO occlusion category, and the Amplatzer™ PFO Occluder has sustained leadership over decades of use and was the first device supported by positive trial results.
Treatment optionsThe Amplatzer™ PFO Occluder was studied in the RESPECT Trial in the US and Canada. The trial enrolled 980 patients, between the ages of 18 to 60, who were diagnosed with a PFO and a cryptogenic stroke. Patients were randomly assigned to either receive the Amplatzer™ PFO Occluder plus blood-thinning medication, or blood-thinning medication alone. The patients were assessed at 30 days, six months, one year and yearly thereafter. The RESPECT Trial was designed to evaluate whether PFO closure with the Amplatzer™ PFO Occluder plus blood-thinning medication was more effective in reducing the risk of another ischemic stroke compared with the sole use of blood-thinning medication. Over a median follow-up period of 5.9 years, the rate of recurrent ischemic stroke was 45% lower with PFO closure compared to medical management exclusively.⁴
In the CLOSE Trial, 663 patients received either the Amplatzer™ PFO Occluder or another approved PFO occluder. This trial showed a 97% stroke risk reduction in patients who underwent PFO closure plus antiplatelet therapy compared to patients who received antiplatelets only.³
About the Amplatzer™ PFO OccluderWe can do better in stroke prevention by using them (Amplatzer PFO) in the appropriate patient.”
Three extensive clinical studies have confirmed the superiority of PFO closure to medical management in reducing the risk of stroke recurrence. ³⁻⁵
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